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    CSNK1G2 casein kinase 1 gamma 2 [ Homo sapiens (human) ]

    Gene ID: 1455, updated on 5-Mar-2024

    Summary

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    Official Symbol
    CSNK1G2provided by HGNC
    Official Full Name
    casein kinase 1 gamma 2provided by HGNC
    Primary source
    HGNC:HGNC:2455
    See related
    Ensembl:ENSG00000133275 MIM:602214; AllianceGenome:HGNC:2455
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CK1g2
    Summary
    Enables protein serine/threonine kinase activity. Involved in peptidyl-serine phosphorylation. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis (RPKM 21.2), spleen (RPKM 15.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    19p13.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (1941172..1981338)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (1912501..1953837)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (1941171..1981337)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9753 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9754 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13635 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1907977-1908788 Neighboring gene secretory carrier membrane protein 4 Neighboring gene adenosine deaminase tRNA specific 3 Neighboring gene Sharpr-MPRA regulatory region 4132 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13636 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:1938387-1938587 Neighboring gene uncharacterized LOC105372238 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9755 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9756 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13637 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13638 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1946998-1947718 Neighboring gene CSNK1G2 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1954929-1955880 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1979763-1980263 Neighboring gene uncharacterized LOC124904610 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1993311-1993811 Neighboring gene BTB domain containing 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:2012303-2012494 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9757 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9758 Neighboring gene uncharacterized LOC107985278 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr19:2028556-2029190

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Polymorphisms of casein kinase I gamma 2 gene associated with simple febrile seizures in Chinese Han population. Yinan M, et al. Neurosci Lett, 2004 Sep 16. PMID 15342122
    2. [Five single nucleotide polymorphisms of casein kinase I gamma 2 gene in children with familial febrile convulsions]. Ma YN, et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2004 Aug. PMID 15300631
    3. Cloning and chromosomal mapping of human casein kinase I gamma 2 (CSNK1G2). Kitabayashi AN, et al. Genomics, 1997 Nov 15. PMID 9403068
    4. CSNK1G2 differently sensitizes tamoxifen-induced decrease in PI3K/AKT/mTOR/S6K and ERK signaling according to the estrogen receptor existence in breast cancer cells. Nguyen Hoang AT, et al. PLoS One, 2021. PMID 33861751, Free PMC Article
    5. MicroRNA-155 regulates casein kinase 1 gamma 2: a potential pathogenetic role in chronic lymphocytic leukemia. Zhang T, et al. Blood Cancer J, 2017 Sep 8. PMID 28885613, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CSNK1G2 differently sensitizes tamoxifen-induced decrease in PI3K/AKT/mTOR/S6K and ERK signaling according to the estrogen receptor existence in breast cancer cells.
      Title: CSNK1G2 differently sensitizes tamoxifen-induced decrease in PI3K/AKT/mTOR/S6K and ERK signaling according to the estrogen receptor existence in breast cancer cells.
    2. IRS4, as a new substrate of CHIP, is negatively regulated by CK1gamma2 at the posttranslational level.
      Title: Phosphorylation of IRS4 by CK1γ2 promotes its degradation by CHIP through the ubiquitin/lysosome pathway.
    3. MicroRNA-155 regulates casein kinase 1 gamma 2: a potential pathogenetic role in chronic lymphocytic leukemia
      Title: MicroRNA-155 regulates casein kinase 1 gamma 2: a potential pathogenetic role in chronic lymphocytic leukemia.
    4. These results indicate that CKIgamma2 hyperphosphorylates the serine-repeat motif of CERT, thereby inactivating CERT and down-regulating the synthesis of sphingomyelin.
      Title: Casein kinase I{gamma}2 down-regulates trafficking of ceramide in the synthesis of sphingomyelin.
    5. Data indicate that SNPs rs740423, rs2277737, rs1059684 of CSNK1G2 gene may contribute to familial febrile convulsions in children.
      Title: [Five single nucleotide polymorphisms of casein kinase I gamma 2 gene in children with familial febrile convulsions].
    6. Ligand-dependent ubiquitination of Smad3 is regulated by CK1g2, an inhibitor of TGF-beta signaling.
      Title: Ligand-dependent ubiquitination of Smad3 is regulated by casein kinase 1 gamma 2, an inhibitor of TGF-beta signaling.
    7. Observational study of gene-disease association. (HuGE Navigator)
      Title: Polymorphisms of casein kinase I gamma 2 gene associated with simple febrile seizures in Chinese Han population.
    8. CK1epsilon and CK1gamma2 were found to bind to Per1 and to promote its degradation
      Title: SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein.
    9. MTA1s interacts with CKI-gamma2, which can phosphorylate MTA1s in an antiestrogen-dependent manner.Estrogen stimulates CKI-gamma2. CKI-gamma2 phosphorylates and modulates the functions of MTA1s.
      Title: Metastatic tumor antigen 1 short form (MTA1s) associates with casein kinase I-gamma2, an estrogen-responsive kinase.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sphingolipid biosynthetic process TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    casein kinase I isoform gamma-2; casein kinase I
    Names
    CKI-gamma 2
    NP_001310.3
    XP_005259555.1
    XP_005259556.1
    XP_005259557.1
    XP_005259558.1
    XP_016881787.1
    XP_047294140.1
    XP_047294141.1
    XP_047294142.1
    XP_054175815.1
    XP_054175816.1
    XP_054175817.1
    XP_054175818.1
    XP_054175819.1
    XP_054175820.1
    XP_054175821.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001319.7 → NP_001310.3  casein kinase I isoform gamma-2

      See identical proteins and their annotated locations for NP_001310.3

      Status: VALIDATED

      Source sequence(s)
      AC005306, AC012615
      Consensus CDS
      CCDS12077.1
      UniProtKB/Swiss-Prot
      B5BU42, O00704, P78368, Q8WUB1
      Related
      ENSP00000255641.7, ENST00000255641.13
      Conserved Domains (1) summary
      cd14126
      Location:45 → 332
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      1941172..1981338
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005259498.2 → XP_005259555.1  casein kinase I isoform X1

      See identical proteins and their annotated locations for XP_005259555.1

      Conserved Domains (2) summary
      COG0515
      Location:45 → 398
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd14126
      Location:45 → 362
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma

    2. XM_005259500.2 → XP_005259557.1  casein kinase I isoform X2

      Conserved Domains (3) summary
      COG0515
      Location:45 → 393
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd14126
      Location:45 → 332
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:332 → 399
      CK1gamma_C; Casein kinase 1 gamma C terminal

    3. XM_047438186.1 → XP_047294142.1  casein kinase I isoform X6

    4. XM_047438184.1 → XP_047294140.1  casein kinase I isoform X1

    5. XM_047438185.1 → XP_047294141.1  casein kinase I isoform X3

      UniProtKB/Swiss-Prot
      B5BU42, O00704, P78368, Q8WUB1

    6. XM_005259499.4 → XP_005259556.1  casein kinase I isoform X1

      See identical proteins and their annotated locations for XP_005259556.1

      Conserved Domains (2) summary
      COG0515
      Location:45 → 398
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd14126
      Location:45 → 362
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma

    7. XM_005259501.2 → XP_005259558.1  casein kinase I isoform X4

      Conserved Domains (3) summary
      COG0515
      Location:21 → 345
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd14126
      Location:15 → 284
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:284 → 351
      CK1gamma_C; Casein kinase 1 gamma C terminal

    8. XM_017026298.1 → XP_016881787.1  casein kinase I isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      1912501..1953837
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054319840.1 → XP_054175815.1  casein kinase I isoform X1

    2. XM_054319842.1 → XP_054175817.1  casein kinase I isoform X2

    3. XM_054319846.1 → XP_054175821.1  casein kinase I isoform X6

    4. XM_054319841.1 → XP_054175816.1  casein kinase I isoform X1

    5. XM_054319843.1 → XP_054175818.1  casein kinase I isoform X3

      UniProtKB/Swiss-Prot
      B5BU42, O00704, P78368, Q8WUB1

    6. XM_054319844.1 → XP_054175819.1  casein kinase I isoform X4

    7. XM_054319845.1 → XP_054175820.1  casein kinase I isoform X5

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P78368.1 GenPept UniProtKB/Swiss-Prot:P78368

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